Pathogens

Defending against infection

Pathogens are microorganisms - such as bacteria and viruses - that cause disease. Bacteria release toxins, and viruses damage our cells. White blood cells can ingest and destroy pathogens. They can produce antibodies to destroy pathogens, and antitoxins to neutralise toxins.

In vaccination pathogens are introduced into the body in a weakened form. The process causes the body to produce enough white blood cells to protect itself against the pathogens, while not getting diseased.

Antibiotics are effective against bacteria, but not against viruses. Some strains of bacteria are resistant to antibiotics.

Pathogens - bacteria

Pathogens are microorganisms that cause infectious disease. Bacteria and viruses are the main pathogens.

Bacteria

Structure of a salmonella bacterium cell

Pathogens - viruses

A hepatitis C virus showing DNA enclosed in a protein coat.

Viruses are many times smaller than bacteria. They are among the smallest organisms known and consist of a fragment of genetic material inside a protective protein coat.

Viruses can only reproduce inside host cells, and they damage the cell when they do this. A virus can get inside a cell and, once there, take over and make hundreds of thousands of copies of itself. Eventually the virus copies fill the whole host cell and burst it open. The viruses are then passed out in the bloodstream, the airways, or by other routes.

Diseases caused by viruses include:

• influenza - flu
• colds
• measles
• mumps
• rubella
• chicken pox
• AIDS

Vaccination

People can be immunised against a pathogen through vaccination. Different vaccines are needed for different pathogens.

Vaccination involves putting a small amount of an inactive form of a pathogen, or dead pathogen, into the body. Vaccines can contain:

• live pathogens treated to make them harmless
• harmless fragments of the pathogen
• toxins produced by pathogens
• dead pathogens

These all act as antigens. When injected into the body, they stimulate white blood cells to produce antibodies against the pathogen.

Because the vaccine contains only a weakened or harmless version of a pathogen, the vaccinated person is not in danger of developing disease - although some people may suffer a mild reaction. If the person does get infected by the pathogen later, the required lymphocytes are able to reproduce rapidly and destroy it.

Vaccines and boosters

Vaccines in early childhood can give protection against many serious diseases. Sometimes more than one vaccine is given at a time, like the MMR triple vaccine against mumps, measles and rubella.

Sometimes vaccine boosters are needed, because the immune response 'memory' weakens over time. Anti-tetanus injections may need to be repeated every ten years.

Bacteria are microscopic organisms. They come in many shapes and sizes, but even the largest are only 10 micrometres long - 10 millionths of a metre.

Bacteria are living cells and, in favourable conditions, can multiply rapidly. Once inside the body, they release poisons or toxins that make us feel ill. Diseases caused by bacteria include:

• food poisoning
• cholera
• typhoid
• whooping cough
• gonorrhoea - a sexually transmitted disease